Genetic Relationships Between Schizophrenia, Bipolar Disorder, and Schizoaffective Disorder
Alastair G. Cardno Michael J. Owen
3, May 2014
ほとんどがダブっており、下記2つのみ
Abstract
There is substantial evidence for partial overlap of genetic influences on schizophrenia and bipolar disorder, with family, twin, and adoption studies showing a genetic correlation between the disorders of around 0.6.
Schizoaffective disorder has been less investigated but shows substantial familial overlap with both schizophrenia and bipolar disorder.
A twin analysis is consistent with genetic influences on schizoaffective episodes being entirely shared with genetic influences on schizophrenic and manic episodes, while association studies suggest the possibility of some relatively specific genetic influences on broadly defined schizoaffective disorder, bipolar subtype.
Table 2.
Table 3.
Alastair G. Cardno Michael J. Owen
3, May 2014
| Nearest Gene 韓国人固有の変異数、非同義変異数 |
|---|
| MIR137 27,0 |
| VRK2 191,2 |
| ZNF804A 129,1 |
| PCGEM1 10,0 |
| MHC 0 |
| MMP16 90,0 |
| CSMD1 1786, 1、SNV-35が1、 |
| LSM1 24,0 |
| CNNM2 51 |
| NT5C2 26,1 |
| AMBRA1 73,1 |
| NRGN 2,0 |
| CCDC68 18,1 |
| TCF4 147,0 |
| ODZ4 0 |
| CACNA1C 302,1 |
| NCAN 17,0 |
| ZNF804A 129,1 |
| ITIH3-ITIH4 13,0 |
| ANK3 229,2 |
ほとんどがダブっており、下記2つのみ
| Nearest Gene |
|---|
| STT3A 13,0 |
| SYNE1 170、6 |
Abstract
There is substantial evidence for partial overlap of genetic influences on schizophrenia and bipolar disorder, with family, twin, and adoption studies showing a genetic correlation between the disorders of around 0.6.
Schizoaffective disorder has been less investigated but shows substantial familial overlap with both schizophrenia and bipolar disorder.
A twin analysis is consistent with genetic influences on schizoaffective episodes being entirely shared with genetic influences on schizophrenic and manic episodes, while association studies suggest the possibility of some relatively specific genetic influences on broadly defined schizoaffective disorder, bipolar subtype.
Table 2.
Genome-Wide Association Study Findings for Schizophrenia and Bipolar Disorder From the Review by Sullivan et al 70
| Phenotype | Chromosome Where Marker Is Located | Nearest Gene | OR |
|---|---|---|---|
| Schizophrenia | 1 | MIR137 | 1.12 |
| 2 | VRK2 | 1.09 | |
| 2 | ZNF804A | 1.10 | |
| 2 | PCGEM1 | 1.20 | |
| 6 | MHC | 1.22 | |
| 8 | MMP16 | 1.10 | |
| 8 | CSMD1 | 1.11 | |
| 8 | LSM1 | 1.19 | |
| 10 | CNNM2 | 1.10 | |
| 10 | NT5C2 | 1.15 | |
| 11 | AMBRA1 | 1.25 | |
| 11 | NRGN | 1.12 | |
| 18 | CCDC68 | 1.09 | |
| 18 | TCF4 | 1.20 | |
| Bipolar disorder | 11 | ODZ4 | 1.14 |
| 12 | CACNA1C | 1.14 | |
| 19 | NCAN | 1.17 | |
| Schizophrenia and bipolar disorder combined | 2 | ZNF804A | 1.11 |
| 3 | ITIH3-ITIH4 | 1.12 | |
| 10 | ANK3 | 1.22 | |
| 12 | CACNA1C | 1.11 |
Table 3.
Disorder Specificity of Genome-Wide Association Study Findings for Schizophrenia and Bipolar Disorder in the Psychiatric Genomics Consortium Cross-Disorder Group Study of 5 Psychiatric Disorders (2013) 73
| Phenotype in Original GWAS | Chromosome Where Marker Is Located | Nearest Gene | Disorders Showing Association |
|---|---|---|---|
| Schizophrenia | 1 | MIR137 | SZ, ASD |
| 2 | PCGEM1 | SZ, ASD | |
| 6 | MHC | SZ | |
| 8 | MMP16 | SZ | |
| 8 | CSMD1 | SZ | |
| 10 | CNNM2 | SZ, MDD | |
| 10 | NT5C2 | SZ, BPD, MDD, ASD, ADHD | |
| 11 | STT3A | SZ | |
| 18 | CCDC68 | SZ, BPD, MDD | |
| 18 | TCF4 | SZ, ASD | |
| Bipolar disorder | 6 | SYNE1 | BPD |
| 10 | ANK3 | BPD | |
| 11 | ODZ4 | BPD | |
| 12 | CACNA1C | BPD, SZ, MDD |
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