The CSMD1 genome-wide associated schizophrenia risk variantrs10503253 affects general cognitive ability and executive function inhealthy males

Erasmia Koiliari

17 February 2014

ギリシャ軍の軍人男性1149名をサンプルとし、 CSMD1遺伝子中のrs10503253置換変異を詳細に調べ、統合失調症専門誌に掲載された論文。C→Aへの置換変異について、下記の3パターンで分析している
C/C (n = 772) C/A (n = 291) A/A (n = 36)

韓国人どもは、ノーベル賞は言うまでもなく、私が2018年に3日間かけて調べた結果として、全63もの国際的な科学関連賞の受賞者がただの一人もいないという驚愕のデータを示していた。

かつ、韓国人どもは、CSMD1遺伝子において、韓国人ども固有の変異を大量に有している。

この論文が算出したP値が正しいのであれば、rs10503253置換変異(C→A)は、確実にIQに関連している。ただし、rs10503253は韓国人ども固有の変異ではない。

しかし、CSMD1遺伝子がIQに関連した遺伝子であることは、この論文の分析が正しのであれば、確実である。

abstract

We investigated the neurocognitive effects of the CSMD1 rs10503253 (C/A) polymorphism in a large, demographically homogeneous sample of young, healthy Greek Caucasian males (n = 1149) phenotyped for a wide range of neuropsychological measures, most of which have been shown to be reliable endophenotypes for schizophrenia

The risk ‘A’ allele was associated with poorer performance on measures of general cognitive ability, strategy formation, spatial and visual working memory, set shifting, target detection and planning for problem solving but not for emotional decision making.

Most of these effects were dependent on risk “A” allele dose, with AA and CC homozygotes being the worse and the best respectively, while CA individuals were intermediate. Potential genotype effects in Stroop and verbal memory performance were also suggested by our dataset.

2. Methods

 The LOGOS project examined 1149 randomly selected young male conscripts from the Greek Army (mean age 21.95 ± 3.5; range: 18–29), who met the inclusion/exclusion criteria (see below) between June 2008 and December 2010.

3. Results

. Table 2 shows the association of CSMD1 with IQ and the nine PCA factors as revealed by the QTPHASE. The rs10503253 risk A-allele was significantly associated with lower IQ and worse strategy formation/spatial working memory, planning time, set shifting/rule learning problem solving verbal working memory and sustained attention before or after covarying for age, education and smoking habits (cigarettes⁄day).

Table 2
Adjusted p-values from permutation test for association of general cognitive ability (IQ) and the nine factors from the principal component analysis of the cognitive variables for CSMD1 rs10503253 polymorphism. p values b 0.005 (Bonferroni corrected) are in bold. P’ refers to p values derived after age, education and cigarettes per day were taken as covariates. The minus symbol signifies lower score in the risk allele A.

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